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In a two-year bioassay of SINEMETno evidence of carcinogenicity was found in rats receiving doses of approximately two times the maximum daily human dose of carbidopa and four times the maximum daily human dose of levodopa.
If you are about to be started on any new medicinetell your doctor and pharmacist that you are taking SINEMET.
Carbidopa allows patients treated for Parkinson’s disease to use much lower doses of levodopaSome patients who responded poorly to levodopa have improved on SINEMETThis is most likely due to decreased peripheral decarboxylation of levodopa caused by administration of carbidopa rather than by a primary effect of carbidopa on the nervous systemCarbidopa has not been shown to enhance the intrinsic efficacy of levodopa.
Standard drugs for Parkinson’s diseaseother than levodopa without a decarboxylase inhibitormay be used concomitantly while SINEMET is being administeredalthough dosage adjustments may be required.
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